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[–]jasonbloom 2 insightful - 1 fun2 insightful - 0 fun3 insightful - 1 fun -  (0 children)

The common symptoms of depression are a sad mood and/or loss of interest in life. Activities that were once pleasurable lose their appeal. Patients may also be haunted by a sense of guilt or worthlessness, lack of hope, and recurring thoughts of death or suicide.

[–]georgewhittington525 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 1 fun -  (0 children)

It's really complicated, and there are many causes of major depression. Factors such as genetic vulnerability, severe life stressors, substances you may take (some medications, drugs and alcohol) and medical conditions can affect the way your brain regulates your moods.