Everything Is Fine! :/

MaximilianKohler · 2024-06-28T07:13:28+00:00

Lemmy is the main alternative.

MaximilianKohler · 2024-05-19T12:16:22+00:00

Related discussions on the human microbiome forum:

MaximilianKohler · 2023-08-14T13:37:51+00:00

Interesting... I posted this to /c/reddit on lemmy.world https://lemmy.world/post/3125497 and it was deleted without any reason/notification and I don't see a way to message the mods. They have a modlog that gave a server error message. Later on I got the modlog to load but it just shows an endless loading icon. There is also no access to your content after it's deleted, unlike with reddit.

I made this comment about some of the drawbacks of Lemmy and I guess this is just another one to add:

I've seen people complain about the phpBB UI, so that made me shy away from using it for my website even though I personally like it.

I started looking into forums some months ago, and in that time Lemmy has already come a long way, to where I think Lemmy would possibly be the better option soon. But I wanted to get my site up and running ASAP.

A few things that factored into my decision:

I think Reddit and its alts need the features of /r/enhancement and /r/Toolbox.

I don't like the default UI of Lemmy. It's too bloated. I'm using old.lemmy.world now but it's definitely lacking in features and a bit buggy (IE: I have to switch to the "regular" site, and log in separately, to edit my post).

I saw beehaw defederate due to lack of mod tools.

lemmy.world showing Lemmy's vulnerabilities (ddos, security, etc.).

I'm still familiarizing myself with Lemmy and the fediverse. It's a bit complex.

The voting system has its upsides and downsides. I think no downvote button is the best option.

I don't like the time-based nature of reddit-type sites. With forums, you don't need to always be there to answer right away. Discussions can take place over longer periods of time.

As you say, a full step-by-step guide is essential.

I'm now very hesitant to trust any 3rd party. I'd have to trust that the Lemmy instance I choose won't do the same thing reddit did to me.

I wasn't really considering hosting my own Lemmy instance at the time. But I think it can be installed onto a subdomain of any website?

MaximilianKohler · 2023-06-18T19:04:33+00:00

Wow, Tildes is absolutely not a good option.

I made a Tildes account many years ago when it first started up. I knew the founder was a Reddit admin, and I'd heard that it was a haven for Reddit admins & power-mods, but I hadn't spent much time there.

I recently made a post about the problems with Reddit, and while there were intelligent people and comments on there, the majority of votes went to people who were being extremely dishonest, and even outright lying; attacking me in every way possible while urging the admin to ban me. Neutral people don't behave like that. So they couldn't have made it more obvious that Tildes is merely an extension of authority-figures-of-Reddit with a different UI. All the same problematic people & behaviors exist there.

Based on the accusations one of them was making, and my history they were pulling up, one of them was either a reddit admin or someone in cahoots with one of the reddit admins that banned me.

The Tildes admin removed my comments debunking the lies they were telling, and deleted my account.

EDIT: Cute. One of the crazy stalkers made a new Saidit account to continue their behavior here. That's some serious dedication.

MaximilianKohler · 2023-06-18T14:03:16+00:00

Lists the problems & benefits of reddit, and argues for viable alternatives.

It covers reddit retaliating against me (seemingly illegally) for being a long-time public critic of theirs. They did something similar to the /r/WatchRedditDie founder.

Is anyone familiar with US laws related to Reddit admins using their position to try to harm me in an act of revenge? Surely there are some limits on what they're legally allowed to do. I imagine it would vary from state to state. My state (CA) bar referral services haven't been very helpful in finding someone familiar with this situation.

MaximilianKohler · 2021-01-17T01:09:49+00:00

The notion that everyone on the left supports the censorship, corruption, abuse, manipulation, etc. that occurs on reddit is wrong.

If you think I want this to be like reddit you didn't comprehend my stance. Corrupt mods on reddit censor the left as well.

MaximilianKohler · 2019-08-28T13:59:58+00:00

It doesn't have to be in bad faith. Think a "duplicate" or "repost" rule. Often there are dozens of articles released by different websites covering the same issue. Some reddit subs resorted to removing them in favor of containing them all in one thread.

MaximilianKohler · 2019-06-29T23:39:24+00:00

You must be thinking of another sub. https://old.reddit.com/r/worldpolitics/ turned into a meme sub due to lack of moderation. People complained about it for years then finally gave up and left.

It's very easy for subs like that to become biased echo-chambers with the wrong mod

I agree, which is why moderation is an important topic that needs to be fixed for any reddit alternative to succeed https://old.reddit.com/r/RedditAlternatives/comments/ay0bc3/what_is_one_feature_you_expect_every_reddit/ehy9aka/. So far I think saidit has a way to go before solving all the problems with reddit.

For example, the problem of "random people who got there first" controlling subs isn't a solved problem here.

Tildes is doing some nice things, but the lack of ability to create a community like /r/fecaltransplant or /r/FMTClinics for example, means they're not a valid replacement in my case.

MaximilianKohler · 2019-06-28T06:51:43+00:00

why would we want more active moderators, and replicate their failed system?

Well reddit subs without active moderation typically turn into low quality fluff. Compare /r/worldpolitics to /r/neutralpolitics. 0 moderation vs heavy moderation. But they mostly have the heavy moderation done right. Whereas other subs like /r/science and /r/askscience have heavy moderation done wrong.

Scroll down to the /r/science & /r/askscience part: https://old.reddit.com/r/rant/comments/aph31h/in_the_age_of_information_information_sharing_is/

MaximilianKohler · 2019-06-26T00:29:28+00:00

I guess reddit did it after they made their source closed?

MaximilianKohler · 2019-06-25T09:54:45+00:00

This please. Not only does the flair not link to anything but you can't search/sort by flair either.

/u/magnora7

MaximilianKohler · 2019-06-25T09:33:49+00:00

Full study: https://sci-hub.tw/https://www.nature.com/articles/s41591-019-0485-4

This is from the Harvard lab trying to make a probiotic from elite athletes.

More useful would be an FMT clinical trial from elite athletes.

MaximilianKohler · 2019-05-29T16:26:45+00:00

Yeah, some category & keyword lists would be useful.

MaximilianKohler · 2019-05-27T08:39:11+00:00

As a disclaimer, I'm not highly familiar with those subs. But IMO, leave that stuff on voat. No need to drown another site in racism and hate.

MaximilianKohler · 2019-05-27T08:30:59+00:00

So now you want the same thing here? Leave the trash on voat.

MaximilianKohler · 2019-05-27T08:24:59+00:00

Probably more important to grow the site (more users) than encourage more activity from people already here.

Personally, I can contribute some science/health stuff, but I'm undecided between here and Tildes and don't have the time to post to both. I'm waiting for this before moving from reddit: https://archive.fo/VleIc#selection-799.0-799.1

MaximilianKohler · 2019-04-06T22:20:29+00:00

or you get both numbers on the same row and it's visually confusing

I dunno, you might want to poll the community with that question/suggestion. I think it may be worthwhile to have some temporary confusion.

Also, there are votes on the side for the submission, but not the comments, so I wonder how it might impact the comment section.

I think it can still be disabled via sub CSS but that's up to the mods of that sub

Only for desktop users, and more and more people are using their telephones to browse the internet. It's a problem I'm currently having with reddit. There's no way to do stuff like disable downvotes for mobile users it seems.

And mobile users seem much more likely to vote without commenting, which makes the situation worse.

MaximilianKohler · 2019-04-05T17:15:23+00:00

Will it though? My suggestion would be to move the "fun" vote from below to side-by-side. New people coming from reddit will still likely see and use it as a replacement downvote.

Also, it would be nice if it could be disabled for serious subs. On reddit you can disable downvote with CSS but it doesn't work for mobile users: https://archive.fo/tJBJ2

MaximilianKohler · 2019-03-30T04:44:27+00:00

they want $$$ and PII

What is PII? How much money are they asking for?

MaximilianKohler · 2019-03-06T23:19:46+00:00

Doxycycline is an antibiotic. To learn about the consequences of overuse of antibiotics see: https://old.reddit.com/r/worldpolitics/comments/a4yeq0/since_there_are_no_rules_here_i_might_as_well_use/

MaximilianKohler · 2019-03-01T02:18:51+00:00

I'm not sure. I'm not knowledgeable enough on that to comment.

But I am very knowledgeable on antibiotics and the microbiome, and to me antibiotics seem like a much bigger threat/harm.

MaximilianKohler · 2019-03-01T02:12:04+00:00

That's a misleading statement on your part.

You have to look at the rates of vaccine injury vs rates of injury from the diseases the vaccines protect against. You also have to look at the severity of the injuries.

I think the science backing the gut microbiome as the causative factor is the strongest: https://old.reddit.com/r/HumanMicrobiome/wiki/intro#wiki_autism.3A

Though the gut microbiome also impacts vaccine efficacy & immune system: https://old.reddit.com/r/HumanMicrobiome/wiki/immunesystem

MaximilianKohler · 2019-03-01T02:08:47+00:00

A web search gives me these responses:

https://www.snopes.com/fact-check/bad-medicine/

https://leftbrainrightbrain.co.uk/2017/02/10/a-look-back-at-the-so-called-cdc-whistleblower-story-and-how-vaxxed-is-misleading/

MaximilianKohler · 2019-02-24T04:27:55+00:00

You're misinformed about vaccines. You have a tremendous amount of information at your fingertips via a simple web search. Use that instead of making ignorant guesses.

There are some knowledge resources in these comments: https://archive.fo/MpwmK#selection-2331.8-2335.0

MaximilianKohler · 2019-02-20T00:04:47+00:00

Well the "great tool for eugenics" is an antibiotic that is extremely common, and often for trivial things like acne.

In my opinion the situation is quite dire: https://old.reddit.com/r/worldpolitics/comments/a4yeq0/since_there_are_no_rules_here_i_might_as_well_use/

MaximilianKohler · 2019-02-15T11:12:37+00:00

EDC = endocrine disrupting chemical. https://www.who.int/ceh/risks/cehemerging2/en/

Highlights

• Doxycycline may be EDCs through mitochondrial dysfunction mechanism cause endocrine disruption.

• Early-life exposure to doxycycline shows negative outcomes of testis health in later-life.

• Early-life exposure to low-dose of doxycycline associates with increased risk of obesity.

Abstract

Veterinary tetracyclines drugs are emerging organic pollutants detected at high concentrations in the urine of school children and a potential public health risk. However, the implications of early-life exposure to tetracyclines on testosterone production, being new endocrine disruptors, remain unknown. We investigated whether the early-life exposure to low-doxycycline, a widely used tetracycline, on mitochondria dysfunction and testosterone disruption in Leydig cells in vitro and in vivo. Next, we determined the mRNA levels of testis cells markers for early-life exposure to low-doxycycline outcomes of testis health in later-life. Finally, we compared the weight gain performance exposed to low- and therapeutic-doses through 15 weeks and examined the role of the microbiota during development. Our results showed doxycycline disturbed steroidogenesis process by mitochondrial dysfunction in mouse Leydig tumor cell line (MLTC-1) cells in vitro. Leydig cells mitochondrial function was disrupted by early-life exposure to low-doxycycline from birth to 49 days, causing testosterone deficiency and decreased quality of the sperm in mice. Early-life exposure to low-doxycycline significantly altered the mRNA levels of key genes in Leydig cells (Cyp11a1, Cyp17a1 and 17β-HSD) and spermatogenic cells (Grfal, Plzf, and Stra8) in later-life in mice. Subchronic low- and therapeutic-doses doxycycline changed gut microbiota differences in diversity reduction and compositional alteration. Moreover, the weight gain effects of doxycycline were only observed in low-dose in male mice. Overall, these results provide insight into the effects of doxycycline on both testis and gut microbiota health. The results provide insight that environmental antibiotics are needed additional research to classify as ECDs.

MaximilianKohler · 2019-02-15T00:11:16+00:00

Subs dominating topics is part and parcel of the sub system, it's how it works, for better or worse.

We have the random sub button, that can help people discover stuff. Also the /all page. What do you imagine other than that?

I think what I quoted Darto doing seems pretty easy and great.

For example, instead of subscribing people to all subs, have a page of categories, so when they choose "science" they get a page full of science-related subs to choose from. Probably with the name of each sub should be a short description that can be used to differentiate them.

Subs dominating topics is part and parcel of the sub system, it's how it works, for better or worse.

I think this is a pretty major flaw of reddit that can and should be addressed.

MaximilianKohler · 2019-02-15T00:07:43+00:00

What do you want to use the most from RES?

I guess mostly the tags and vote tallies on individual users. I use the macros a lot on reddit.

I don't really notice stuff till it's gone, but looking through the settings the formatting links is another. New comment count + highlighting of new comments.

/r/toolbox addon is just as important as RES IMO.

MaximilianKohler · 2019-02-15T00:02:25+00:00

Fixed now.

MaximilianKohler · 2019-02-14T15:01:14+00:00

On this page https://saidit.net/subs it would be nice to have a "1-50 of 226". As is, there's only a "next" button with no indication of how many pages or total subs.

Also, any plans on preventing one sub from dominating a topic? Such as /s/science vs /s/sciences? On reddit, the latter one would virtually never be able to compete.

Darto for example is trying to address this via:

through a Discover page where users can find new and trending communities, a global tag system so one community doesn't own a specific topic

Also, I think somewhere else you linked to a page of your "to do" list, but maybe add that link to this OP?

MaximilianKohler · 2019-02-14T14:59:39+00:00

For firefox, you have to do it every time you restart your browser huh? It does seem to be temporary. /u/d3rr

MaximilianKohler · 2019-02-14T13:12:22+00:00

Thanks :)

I've been following the microbiome literature very closely, and the wiki here is very extensive as well.

MaximilianKohler · 2019-02-14T13:10:38+00:00

I copied over the css from the reddit sub. I've changed that line. Did it fix it?

MaximilianKohler · 2019-02-14T13:10:26+00:00

Someone reported this as spam. I don't think it's spam, but it's better to use sites that directly link to the study, or share the study in the comments.

MaximilianKohler · 2019-02-13T23:04:17+00:00

Great, thanks!

MaximilianKohler · 2019-02-04T04:44:22+00:00

List of source of strains:

EDIT: here's a project with a list of strains that /u/markus_naslund has started: https://old.reddit.com/r/HumanMicrobiome/comments/aceyab/commercially_available_probiotic_strain_database/

You can PM me for additions so I can keep this updated. If google will not tell you the source you'll have to contact the company and ask. The vast majority are food-sourced so it might be easier to just keep a list of human-sourced.

We have to keep in mind that there is a difference between strains sourced from human stool (which may be transient environmental microbes) and strains sourced from the intestinal wall (which are more likely to be host native). Then we have to keep in mind that not every human-sourced probiotic will be beneficial, or significantly so. Which is why I primarily focus on FMT, and wait till there are proven benefits for new/old strains and simply list the main ones here.

Human-sourced:

Culturelle (L.GG): https://en.wikipedia.org/wiki/Lactobacillus_rhamnosus#Lactobacillus_rhamnosus_GG_.28ATCC_53103.29
Align (b.infantis 35624): http://www.bifantis.com/pdf/Monograph.pdf
BioGaia Gastrus: https://www.biogaia.com/research/biogaia-probiotic-strains/
B. longum BB536: http://maypro.com/products/morinaga-bb536 - http://www.morinu.com/en/b-longumbb536/
Lactobacillus gasseri CP2305: https://archive.is/BLZzv
Lactobacillus plantarum 299v: https://www.fda.gov/downloads/Food/IngredientsPackagingLabeling/GRAS/NoticeInventory/ucm544492.pdf - http://www.jarrow.com/articles/release/id/417/Lactobacillus_Plantarum_299v,_Natural_Solutions_to_GI_Problems
Mutaflor E.Coli Nissle 1917: http://www.probiotics-help.com/mutaflor.html - https://archive.is/jrie0
Super Human Probiotics - claims to have 15 human-sourced strains + 4 food sourced: https://elementalwizdom.com/products/super-human-probiotics
AOR Probiotic 3: Under their "label info" tab they say 2 out of 3 are human-sourced: http://www.aor.ca/en/product/PROBIOTIC-3

Food-sourced:

VSL#3: https://vsl3.com/faq/ - from what I can tell, the only thing unique about this product is the high CFU count. The strains weren't even identified/studied till 02/2018: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192452
Most/all Garden Of Life products: See the label.

Unknown source:

Reuteri pearls: https://archive.is/luQNi

MaximilianKohler

MODERATOR OF

List of source of strains:

Human-sourced:

Food-sourced:

Unknown source: